Also, if you 're using a Wireless mouse replace its batteries. The first step to fix mouse (or keyboard) issues is to disconnect and reconnect the mouse on the computer, or to connect the mouse to another USB port.
How to Troubleshoot Problems with your Mouse. In this troubleshooting guide you 'll find detailed steps to resolve problems with your USB or PS2 mouse or the touchpad on an Windows 10, 8, 7 or Vista based computer. So, proceed and replace the mouse, but shutdown your PC first (press the Power button continually, until the power indicator lights becomes Off), before connecting the new mouse. In most cases, the mouse (or keyboard) related problems is hardware issues. Problem in details: The user is able to move the mouse cursor on the screen, but the click doesn't work and the only way to bypass the problem temporarily is to press Ctrl + Alt +Del & Esc.
The 'Mouse Moves but Cannot Click' problem can appear suddenly, when using an external USB mouse or a Touchpad on Windows 7, 8 or 10 based computer or laptop.