I also have this keyboard and mouse package at home on a Dell desktop with the same operating systems and office package and it does exactly the same thing. My problem is, when I change screen or window and start to type, the keyboard misses the first letter…each and every time. I also have two screens in addition to the laptop screen. I'm working with Windows 10 Pro on a Dell Ultrabook, Intel I5 64bit X64 and O365 and Office 2016. I have a Microsoft Sculpt wireless keyboard with separate keypad.